Rinse squash under running tap water and dry them with a paper towel. Slice them into ¼ inch slices. Try to make even slices for a uniform cook time.
In a small shallow bowl, whisk together the buttermilk, egg, and hot sauce (optional) until fully combined and set aside.
In a second shallow bowl, combine all dry ingredients - flour, cornmeal, Italian seasoning, Creole/Cajun Seasoning, garlic powder, onion powder, salt, and pepper. Mix well.
Dredge the sliced squash circles in the buttermilk and egg mixture, followed by the cornmeal mixture, ensuring they are completely coated. Shake off any excess cornmeal mixture from the squash, then place them in a single layer on a baking sheet while you finish the rest.
Let the squash sit for 2-3 minutes to help the cornmeal mixture stick to the squash.
Heat approximately half an inch of oil over medium-high heat in a large deep skillet.
When the oil gets hot, place the squash in the oil using a slotted spoon or tongs. Fry the squash until golden brown and crisp for about 3-4 minutes on each side.
Transfer fried squash to a paper-towel-lined plate to soak off excess oil.
Allow the squash to cool for about 2 minutes, then serve immediately with ranch dip, ketchup, or your favorite dipping sauce.